Role of MicroRNAs in Renin-Angiotensin-Aldosterone System-Mediated Cardiovascular Inflammation and Remodeling

Role of MicroRNAs in Renin-Angiotensin-Aldosterone System-Mediated Cardiovascular Inflammation and Remodeling

Blog Article

MicroRNAs are endogenous regulators of gene expression either by inhibiting translation or protein degradation.Recent studies indicate that microRNAs play a role in cardiovascular disease and renin-angiotensin-aldosterone system- (RAAS-) mediated cardiovascular inflammation, either as mediators or being targeted by RAAS pharmacological inhibitors.The exact role(s) of microRNAs in RAAS-mediated cardiovascular inflammation and remodeling Insulated Bottle Holder is/are still in early stage of investigation.However, few microRNAs have been shown to play a role in RAAS signaling, particularly miR-155, miR-146a/b, miR-132/122, and miR-483-3p.Identification of specific microRNAs and their targets and elucidating microRNA-regulated mechanisms associated RAS-mediated cardiovascular inflammation and remodeling might lead to the development of novel pharmacological strategies to target RAAS-mediated vascular pathologies.

This paper reviews Bosch HBA5780S0B Serie 6 Multifunction Electric Built-in Single Oven microRNAs role in inflammatory factors mediating cardiovascular inflammation and RAAS genes and the effect of RAAS pharmacological inhibition on microRNAs and the resolution of RAAS-mediated cardiovascular inflammation and remodeling.Also, this paper discusses the advances on microRNAs-based therapeutic approaches that may be important in targeting RAAS signaling.